ZEE is Benzodiazepine derivative, Anticonvulsant, antipanic, muscle relaxant. Clonazepam binds to the BZD receptor in the CNS. The binding will facilitate GABA mediated chloride channel opening and produce hyperpolarisation. This will result in an increase in the concentration of the inhibitory neurotransmitter GABA and decreases firing rate of neuron. This in turn alters normal functions of the body. Clonazepam also blocks Pentylenetetrazol which is responsible for seizure production and therefore Clonazepam is useful in the treatment of epilepsy. Absorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Most metabolites are excreted in urine
Benzodiazepine derivative, Anticonvulsant, antipanic, muscle relaxant.
Pharmacokinetics: Absorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Most metabolites are excreted in urine
Pregnancy Information: ['Contraindicated']
Overdose Effect: Give supportive measures and symptomatic treatment. Gastric lavage has to be done. Flumazenil can be given as antagonist. Hypotension can be treated with vasopressors.
Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose