VALP-ER is Carboxylic acid derivative, Histone Deacetylase Inhibitor, Anticonvulsants, Mood stabilizers ,antimigraine agent. Divalproex is an antiepileptic agent. It dissociates in the gastrointestinal tract into 2 molecules of Valproic acid and this Valproic acid produces therapeutic response by following mechanism. Valproic acid prolongs the inactivated state of voltage sensitive neuronal sodium ion channel either by increasing the efflux or by decreasing the influx of sodium ion across the cell membrane and inhibits the high frequency neuronal discharge.It blocks the propagation of neuronal impulses. Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body in protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: It is excreted mainly in urine and small amount in faeces, exhaled air and breast milk.
Carboxylic acid derivative, Histone Deacetylase Inhibitor, Anticonvulsants, Mood stabilizers ,antimigraine agent.
Pharmacokinetics: Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body in protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: It is excreted mainly in urine and small amount in faeces, exhaled air and breast milk.
Pregnancy Information: ['Use with caution']
Overdose Effect: Give supportive measures and symptomatic treatment. Naloxone can be given to reverse CNS, respiratory depression and anticonvulsant action of Valproic acid.
Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.