EPRIL is Angiotensin converting enzyme (ACE) inhibitor, Antihypertensive. It is a prodrug and converted in to active Enalaprilat; which is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. It has no effect on cardiac output and cardiovascular reflexes. And there is little dilatation of capacitance vessels; so postural hypotension is not a problem. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure. Absorption: Absorbed orally up to60%
Angiotensin converting enzyme (ACE) inhibitor, Antihypertensive.
Pharmacokinetics: Absorption: Absorbed orally up to60%
Pregnancy Information: ['Contraindicated']
Overdose Effect: Treatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases haemodialysis is considered if required. Treatment includes I.V. infusion of normal saline solution.
Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.