CYTARABINE is In the body this cytosine arabinoside is converted into active arabinoside triphosphate.This nucleotide compete with the physiological substrate deoxy cytidine5`-triphosphate for incorporation into DNA by DNA polymerase. This results the mitosis inhibition which is essential for the rapid dividing cells. It also inhibits the RNA polymerase and nucleotide reductase enzyme (needed for the DNA synthesis). Absorption- Rapidly absorbed after intravenous, intramuscular and intrathecal administration.
Pharmacokinetics: Absorption- Rapidly absorbed after intravenous, intramuscular and intrathecal administration.
Pregnancy Information: ['Contraindicated']
Overdose Effect: Give supportive and symptomatic treatment. Transfuse the blood component and emesis.
Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.