CUFLOX is Third generation fluoroquinolone (or quinolone), A broad spectrum antiinfective. Levofloxacin is a broad spectrum antibacterial agent. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Levofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis. Absorption: It is rapidly and completely absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes insignificant metabolism in the liver. Excretion: Drug is excreted mainly through urine.
Third generation fluoroquinolone (or quinolone), A broad spectrum antiinfective.
Pharmacokinetics: Absorption: It is rapidly and completely absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes insignificant metabolism in the liver. Excretion: Drug is excreted mainly through urine.
Pregnancy Information: ['Contraindicated.']
Overdose Effect: Give supportive measures and symptomatic treatment. Empty the stomach. Maintain appropriate hydration.
Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.