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CRESTOR 20 mg - Tablet

CRESTOR is Statin, HMG-CoA Reductase Inhibitor, Antilipemic. It is a hypolipidaemic statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels. Absorption: Readily absorbed orally, and bioavailability is about 20%. Distribution: Widely distributed in a protein bound form, Metabolism: Not significantly metabolized in liver, only about 10% is metabolized in liver. Excretion: Excreted mainly through bile.

Statin, HMG-CoA Reductase Inhibitor, Antilipemic.

Pharmacokinetics: Absorption: Readily absorbed orally, and bioavailability is about 20%. Distribution: Widely distributed in a protein bound form, Metabolism: Not significantly metabolized in liver, only about 10% is metabolized in liver. Excretion: Excreted mainly through bile.

Pregnancy Information: ['Contraindicated']

Overdose Effect: Provide supportive care and symptomatic treatment

Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose