CLOTAZOLE-OD 200 mg - Tablet

CLOTAZOLE-OD is Selective Phosphodiesterase III Enzyme Inhibitor,quinolinone derivative, Antiplatelet Agent(Platelet Aggregation Inhibitor) The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It inhibits enzyme phosphodiesterase III and causes an increase in cyclic AMP in platelets and blood vessels which results in inhibition of platelet aggregation and vasodilatation. It reversibly inhibits platelet aggregation induced by stimuli; such as thrombin, ADP, collagen, arachidonic acid, epinephrine, stress, etc. The drug also reduces triglyceride level increases HDL cholesterol level. Absorption: Absorbed orally and bioavailability increases when administered along with a fatty meal. Distribution: Widely distributed in a protein bound form, Metabolism: Extensively metabolized in liver in to active metabolites. Excretion: Excreted mainly through urine as metabolites (about 74%), and a portion (about 20%) is excreted through faeces.

Selective Phosphodiesterase III Enzyme Inhibitor,quinolinone derivative, Antiplatelet Agent(Platelet Aggregation Inhibitor)

Pharmacokinetics: Absorption: Absorbed orally and bioavailability increases when administered along with a fatty meal. Distribution: Widely distributed in a protein bound form, Metabolism: Extensively metabolized in liver in to active metabolites. Excretion: Excreted mainly through urine as metabolites (about 74%), and a portion (about 20%) is excreted through faeces.

Pregnancy Information: ['Contraindicated']

Overdose Effect: Carefully observe the patient and give supportive and symptomatic treatment.

Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.