CLOQUIN is 4- Aminoquinoline, excellent schizonticide, Antimalarial, amebicide, anti inflammatory and local irritant. Malarial parasites digest their own haemoglobin and release highly toxic heme. This heme is used up by parasitic polymerase enzyme and converted to non toxic haemozoin.Since Chloroquine is a weak base it has high affinity towards acidic lysosome.Chloroquine inhibits polymerase enzyme and interfere the formation of haemozoin and results in accumulation of toxic haeme and also it binds with haeme to form haeme- Chloroquine complex. These lead to membrane lysis and kill the parasite. Absorption: It is well absorbed after oral administration.Distribution: It is distributed in protein bound form and concentrated in melanin containing cells.Metabolism: some drugs undergo metabolism in the liver. Excretion: It is excreted mainly through urine.
4- Aminoquinoline, excellent schizonticide, Antimalarial, amebicide, anti inflammatory and local irritant.
Pharmacokinetics: Absorption: It is well absorbed after oral administration.Distribution: It is distributed in protein bound form and concentrated in melanin containing cells.Metabolism: some drugs undergo metabolism in the liver. Excretion: It is excreted mainly through urine.
Pregnancy Information: ['Use with caution']
Overdose Effect: Give supportive measures and treatment. Induce emesis or gastric lavage has to be done followed by administration of charcoal. To control seizure Thiopentone can be given to the patient. If necessary peritoneal dialysis may be used
Missed Dosage: Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.