CLEFT is A pyrimidine synthesis inhibitor, Isoxazole derivative, Disease-modifying Antirheumatic Drug. This immunomodulatory drug inhibits dihydroorotate dehydrogenase (an enzyme involved in de novo pyrimidine synthesis) (abbreviation DHODH). It also has anti-inflammatory effect. This double action is slow progression of the disease and to cause remission/relief of symptoms of rheumatoid arthritis and psoriatic arthritis such as joint tenderness and decreased joint and general mobility in human patients. Absorption- Well absorbed after oral administration.
A pyrimidine synthesis inhibitor, Isoxazole derivative, Disease-modifying Antirheumatic Drug.
Pharmacokinetics: Absorption- Well absorbed after oral administration.
Pregnancy Information: ['Contraindicated']
Overdose Effect: Give symptomatic and supportive treatment. Administer activated charcoal to reduce the further absorption of drug.
Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.