CIPRID is A third generation cephalosporin antibiotic, Parenteral antibiotic. Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: It is not significantly metabolized inside the body. Excretion: Excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.
A third generation cephalosporin antibiotic, Parenteral antibiotic.
Pharmacokinetics: Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: It is not significantly metabolized inside the body. Excretion: Excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.
Pregnancy Information: ['Use with caution.']
Overdose Effect: Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Hypoprothrombinemia may also occur. Treatment includes removal of drug from the body by dialysis, administration of vitamin K or blood products & supportive measures
Missed Dosage: Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.