CIMETIDINE 200 mg - Tablet

CIMETIDINE is Histamine H2-receptor antagonist, Antiulcer. Cimetidine is a H2 (Histamine) receptor antagonist.Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP. This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane. Cimetidine reversibly competes with Histamine for binding to H2 receptors on the basolateral membrane of parietal cells and predominantly inhibits basal acid secretion. Absorption: It is rapidly absorbed after oral administration. Distribution: Distributed to body tissues in unbound form. Metabolism: Small amount of Cimetidine undergoes metabolism in the liver. Excretion: It is excreted mainly in urine.

Histamine H2-receptor antagonist, Antiulcer.

Pharmacokinetics: Absorption: It is rapidly absorbed after oral administration. Distribution: Distributed to body tissues in unbound form. Metabolism: Small amount of Cimetidine undergoes metabolism in the liver. Excretion: It is excreted mainly in urine.

Pregnancy Information: ['Use with caution']

Overdose Effect: Give supportive measures and symptomatic treatment. Drug can be removed from the body by inducing emesis and or by gastric lavage. Activated charcoal is given to reduce the absorption of the drug. Tachycardia can be treated with Propranolol. Haemodialysis can be done if necessary.

Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.