CEFOX (JACKSON) is Third Generation cephalosporin Parenteral antibiotic. Cefotaxime is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & aerobic gram negative organisms by inhibiting bacterial cell wall synthesis. Cefotaxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefotaxime Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed, & good CSF penetration, Metabolism: A portion of it is deacetylated in the body in to an active metabolite desacetylcefotaxime, Excretion: Excreted mainly through urine & small amount is seen in breast milk.
Third Generation cephalosporin Parenteral antibiotic.
Pharmacokinetics: Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed, & good CSF penetration, Metabolism: A portion of it is deacetylated in the body in to an active metabolite desacetylcefotaxime, Excretion: Excreted mainly through urine & small amount is seen in breast milk.
Pregnancy Information: ['Use with caution.']
Overdose Effect: Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive measures
Missed Dosage: Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.