CEFOPRIM INJ. is Second Generation Cephalosporin antibiotic. Cefuroxime is a 2nd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefuroxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefuroxime Cefuroxime sodium is orally not well absorbed & should be given parenterally but Cefuroxime axetil is absorbed orally & food increases absorption rate. Distribution: widely distributed, & greater CSF penetration. Metabolism: Not metabolized, Excretion: Excreted mainly through urine & small amount is seen in breast milk.
Second Generation Cephalosporin antibiotic.
Pharmacokinetics: Cefuroxime sodium is orally not well absorbed & should be given parenterally but Cefuroxime axetil is absorbed orally & food increases absorption rate. Distribution: widely distributed, & greater CSF penetration. Metabolism: Not metabolized, Excretion: Excreted mainly through urine & small amount is seen in breast milk.
Pregnancy Information: ['Use with caution']
Overdose Effect: Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive measures.
Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.