CADICIN is Aminoglycoside Antibiotic. Amikacin exerts its bactericidal action against gram- negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1. Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2. Misleading of m-RNA codon by bacterial ribosome, 3. Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters it`s permeability, 4. Bacterial cell lysis. It has broadest spectrum of activity among amino glycosides. Absorption: Poorly absorbed orally, Distribution: Distributed extracellularly. CSF penetration & intraocular penetration poor. Metabolism:
Pharmacokinetics: Absorption: Poorly absorbed orally, Distribution: Distributed extracellularly. CSF penetration & intraocular penetration poor. Metabolism:
Pregnancy Information: ['Contraindicated.']
Overdose Effect: An overdose results in Ototoxicity, nephrotoxicity, neuromuscular disorders & hypersensitivity manifestations. Treatment includes removal of drug by dialysis, &drug treatment with neostigmine, Ca, & Prednisolone.
Missed Dosage: Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.